NSu 8324 - Readings in Neurobiology
Course Description
This course is designed to provide the basic neuroscience underpinnings of neurosurgery for residents. Topics covered include neuroanatomy of the brain and spinal cord, as well as neurophysiology, neurochemistry, and integrative neuroscience.
In-house exams covering these topics will be administered quarterly. Prior to each quarter the residents will be given topic areas for them to focus their studies. In helping to prepare for the examination, a suggested reading list of textbooks, papers, online material, etc., will be provided for self-directed learning. Mastery of this material will satisfy the residency competency requirement that residents must “know and apply the basic sciences” that are appropriate for each residency program.
Module 1: Cell Biology of Neurons and Glia
Cytology of neurons and glia
Ion channels
Membrane potentials
Synaptic transmission
Neurotransmitters
Suggested Readings:
Principles of Neural Science, Ed. by Kandel, Schwartz, and Jessell
Molecular Basis of Neuropharmacology: A Foundation for Clinical Neuroscience, Ed. by Nestler, Hyman, and Malenka
Basic Neurochemistry, Ed. by Segal, Albers, Brady, and Price
Online Resources:
Neuroscience Online Textbook by Purves et al.
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=neurosci.TOC&depth=2
Neuroanatomy Webcast
http://webcast.berkeley.edu/courses/archive.php?seriesid=1906978375
Wikipedia – Science Portal
http://en.wikipedia.org/wiki/Portal:Science
Module 2: Sensory Systems
Somatic sensation
Spinothalamic pain pathways
Dorsal column pathways for touch sensation
Thalamocortical pathways for touch and pain
Vision
Retinal organization
Retino-geniculate pathways
Cortical representation of vision
Hearing
Anatomical organization of the cochlea
Transduction of sound sensation
Smell and taste
Suggested Readings:
Principles of Neural Science, Ed. by Kandel, Schwartz, and Jessell
Neuroanatomy Through Clinical Cases, by Blumenfeld
Online Resources:
Neuroscience Online Textbook by Purves et al.
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=neurosci.TOC&depth=2
Neuroanatomy Webcast
http://webcast.berkeley.edu/courses/archive.php?seriesid=1906978375
Wikipedia – Science Portal
http://en.wikipedia.org/wiki/Portal:Science
Module 3: Motor, Cognitive, and Autonomic Systems
Motor Systems
Spinal reflexes
Vestibular system
Motor cortex and voluntary movement
Basal ganglia
Cerebellum
Cognition and the Limbic System
Autonomic Systems
Sympathetic autonomic nervous system
Parasympathetic autonomic nervous system
Suggested Readings:
Principles of Neural Science, Ed. by Kandel, Schwartz, and Jessell
Neuroanatomy Through Clinical Cases, by Blumenfeld
Online Resources:
Neuroscience Online Textbook by Purves et al.
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=neurosci.TOC&depth=2
Neuroanatomy Webcast
http://webcast.berkeley.edu/courses/archive.php?seriesid=1906978375
Wikipedia – Science Portal
http://en.wikipedia.org/wiki/Portal:Science
Module 4: Molecular Genetics, Brain Tumors, Neuroimmunology, and Cutting Edge Developments
Molecular Genetic of the Nervous System
Hallmarks of Cancer
Molecular Genetics of Glioma
Normal and Brain Tumor Stem Cells
Basic Immunology
Mechanisms and Principles of Immunity in the brain
Cutting Edge: recent clinical trials and emerging trends
Suggested Readings:
For Basic Immunology: Immunobiology 5th ed.
Janeway, Charles A.; Travers, Paul; Walport, Mark; Shlomchik, Mark
New York and London: Garland Science; c2001
(Tip, focus on function and biology of T cell and NK cell; how are they similar and how are they different)
Online Resources:
Molecular Biology of the Cell, by Albers et al.
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=mboc4.TOC&depth=2
Immunobiology, by Janeway et al.
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=imm.TOC&depth=2
Hallmarks of Cancer: review paper 1
Molecular Genetics of Glioma: review paper 2
Immunity in Brain: review paper3
Stem cells & Brain Tumor: review paper4
Cutting Edge, immunotherapy: review paper5
Cutting Edge, gene therapy: review paper 6
DNA Interactive Websites
http://www.dnai.org
http://www.dnaftb.org
http://www.dnalc.org/home.html
Molecular Biology Webcast
http://webcast.berkeley.edu/courses/archive.php?seriesid=1906978371
Cancer Interactive Website
http://www.insidecancer.org/
Wikipedia – Science Portal
http://en.wikipedia.org/wiki/Portal:Science
1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57-70.
2. Sehgal A. Molecular changes during the genesis of human gliomas. Semin Surg Oncol. 1998;14:3-12.
3. Ransohoff RM, Kivisakk P, Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat Rev Immunol. 2003;3:569-581.
4. Vescovi AL, Galli R, Reynolds BA. Brain tumour stem cells. Nat Rev Cancer. 2006;6:425-436.
5. Hussain SF, Heimberger AB. Immunotherapy for human glioma: innovative approaches and recent results. Expert Rev Anticancer Ther. 2005;5:777-790.
6. King GD, Curtin JF, Candolfi M, Kroeger K, Lowenstein PR, Castro MG. Gene therapy and targeted toxins for glioma. Curr Gene Ther. 2005;5:535-557.
NSu 8324 - Neurobiology Self-Examination Questions
Upon completion of the four modules, the self-examination questions can be accessed by going to MyU portal www.myu.umn.edu and signing in. Then go to "My USpace" where the courses are listed and find "NSu 8324 - Neurobiology Self-Examination Questions".
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